In this study, the binding properties of angiotensin receptors were examined in the liver, adrenal, brain, and vascular tissue of the brushtail possum, Trichosurus vulpecula . With super(125)I-Ile super(5)-angiotensin II as the radioligand, the binding affinity (K sub(a)) and receptor number (R sub(o)) were estimated for the liver and adrenal. It was concluded that liver, adrenal, and vascular AII receptors in the marsupial possum have characteristics similar to those in eutherian mammals. However, the failure to find brain AII receptors raises the possibility that those functions mediated by such receptors in the eutherian brain are absent in the possum and perhaps other marsupials.
|Author||C. Sernia, P. Lello and W. G. Thomas|
|Secondary title||General and Comparative Endocrinology|